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Meet Charlotte. She's ready to make history. Are you?

Join me in the Trial-Ready Cohort-Down Syndrome and take part in this important research.

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Volunteers with Down’s syndrome could help find Alzheimer’s drugs

Those with the syndrome have more of a protein implicated in dementia
How to improve clinical trials

Involving more participants can lead to new medical insights
Why Industry Must Design Alzheimer's Trials To Include People With Down Syndrome

Andrea Pfeifer, PhD, discusses the challenges and opportunities of including people with Down syndrome in Alzheimer's disease trials and the potential for anti-amyloid therapies to prevent AD. CNS Drugs, Sept. 2024.
Down Syndrome in a New Era for Alzheimer's Disease

Michael Rafii, MD, PhD, discusses the need for equity and inclusivity in Alzheimer's research to improve the lives of people with Down syndrome. JAMA, Nov. 2023
Down Syndrome Families' Fight for Access to Alzheimer’s Trials, Treatments

Families of children with Down syndrome are leading efforts to increase access to the latest treatments in Alzheimer's research. Reuters, Oct. 2023
Meet Frank. He’s Ready to Make History. Are You?

Frank is a Global Down Syndrome Foundation Research Advocate.
Congressional Briefing on Down Syndrome and Alzheimer's Disease

Lead researcher for TRC-DS, Michael Rafii, MD, PhD, participated in a congressional briefing on the status of research on Alzheimer’s disease in people with Down syndrome. ATRI, July 2023
In a New Study, Vanderbilt Will Look at Alzheimer’s Disease in Those with Down Syndrome

Vanderbilt University Medical Center is recruiting adults with Down syndrome to conduct a new study. News Channel 5, Nashville, March 2023
Alzheimer's Meds are Here. But for the Down Syndrome Community, it's Still the 1980s.

Thirty years ago, the Down syndrome community helped scientists uncover critical learnings about the genetic basis of Alzheimer’s disease. Now, in 2023, we stand on the cusp of new treatments reaching the market. Fierce Biotech, March 2023
Testimonials from Research Participants Who Have Down Syndrome

Watch a video featuring research study participants and why they participate. ACTC, Aug. 2022
For People with Down Syndrome, a Longer Life, but Under a Cloud

People with Down syndrome, which causes intellectual and physical disabilities, are almost never included in clinical trials for drugs to treat or prevent Alzheimer’s, a situation advocates, patients and scientists decry and are trying to change. Washington Post, April 2022
Alzheimer’s Progression in Down Syndrome Appears Similar to Other Genetic, Early Onset Forms of the Disease

An NIH-funded study suggests people with Down syndrome may benefit from Alzheimer’s disease treatments. National Institute on Aging, Dec. 2022
Tracking the Alzheimer's-Down Syndrome Connection

By the time they’re 40, most people with Down syndrome develop beta amyloid plaques in the brain — a key characteristic of Alzheimer’s disease. UC Irvine Health, March 2021
Alzheimer's Disease in People with Down Syndrome

Many but not all people with Down syndrome develop Alzheimer’s disease when they get older. NIH, Nov. 2020
Why I Participate in Alzheimer's Research - Bob's Story

Listen to Bob explain why he participates in research because of his daughter with Down syndrome. National Institute on Aging, July 2019
People with Down Syndrome are Pioneers in Alzheimer's Research

When researchers at the University of California, San Diego wanted to study an experimental Alzheimer's drug last year, they sought help from an unlikely group: people with Down syndrome. NPR, Aug. 2014

Story Spotlight​

Meet Charlotte. She's ready to make history. Are you?

Latest Stories​

Story Spotlight

Latest Stories